Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry
Identifieur interne : 000E20 ( Main/Exploration ); précédent : 000E19; suivant : 000E21Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry
Auteurs : Maxime J. Parent [Canada] ; Marilyn Cyr [Canada] ; Antonio Aliaga [Canada] ; Alexey Kostikov [Canada] ; Esther Schirrmacher [Canada] ; Jean-Paul Soucy [Canada] ; Naguib Mechawar [Canada] ; Pedro Rosa-Neto [Canada] ; Marc-Andre Bedard [Canada]Source :
- EJNMMI Research [ 2191-219X ] ; 2013.
Abstract
Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified
Fifteen male rats (3 months old) underwent a cerebral infusion of 192 IgG-saporin at the level of the nucleus basalis magnocellularis. They were scanned using [18F]FEOBV PET, then sacrificed, and their brain tissues collected for immunostaining and quantification of cholinergic denervation using optical density (OD).
For both PET binding and postmortem OD, the highest losses were found in the cortical areas, with the highest reductions in the orbitofrontal, sensorimotor, and cingulate cortices. In addition, OD quantification in the affected areas accurately predicts [18F]FEOBV uptake in the same regions when regressed linearly.
These findings support [18F]FEOBV as a reliable imaging agent for eventual use in human neurodegenerative conditions in which cholinergic losses are an important aspect.
Url:
DOI: 10.1186/2191-219X-3-70
PubMed: 24103360
PubMed Central: 3852759
Affiliations:
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Parent</name><affiliation wicri:level="1"><nlm:aff id="I1">Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3</wicri:regionArea><wicri:noRegion>QC H4H 1R3</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Université du Québec à Montreal (UQAM), Montreal, QC H3C 3P8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université du Québec à Montreal (UQAM), Montreal, QC H3C 3P8</wicri:regionArea><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Cyr, Marilyn" sort="Cyr, Marilyn" uniqKey="Cyr M" first="Marilyn" last="Cyr">Marilyn Cyr</name><affiliation wicri:level="1"><nlm:aff id="I1">Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3</wicri:regionArea><wicri:noRegion>QC H4H 1R3</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Université du Québec à Montreal (UQAM), Montreal, QC H3C 3P8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université du Québec à Montreal (UQAM), Montreal, QC H3C 3P8</wicri:regionArea><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Aliaga, Antonio" sort="Aliaga, Antonio" uniqKey="Aliaga A" first="Antonio" last="Aliaga">Antonio Aliaga</name><affiliation wicri:level="1"><nlm:aff id="I3">Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4</wicri:regionArea><wicri:noRegion>QC H3A 2B4</wicri:noRegion></affiliation></author><author><name sortKey="Kostikov, Alexey" sort="Kostikov, Alexey" uniqKey="Kostikov A" first="Alexey" last="Kostikov">Alexey Kostikov</name><affiliation wicri:level="1"><nlm:aff id="I3">Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4</wicri:regionArea><wicri:noRegion>QC H3A 2B4</wicri:noRegion></affiliation></author><author><name sortKey="Schirrmacher, Esther" sort="Schirrmacher, Esther" uniqKey="Schirrmacher E" first="Esther" last="Schirrmacher">Esther Schirrmacher</name><affiliation wicri:level="1"><nlm:aff id="I3">Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4</wicri:regionArea><wicri:noRegion>QC H3A 2B4</wicri:noRegion></affiliation></author><author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name><affiliation wicri:level="1"><nlm:aff id="I3">Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4</wicri:regionArea><wicri:noRegion>QC H3A 2B4</wicri:noRegion></affiliation></author><author><name sortKey="Mechawar, Naguib" sort="Mechawar, Naguib" uniqKey="Mechawar N" first="Naguib" last="Mechawar">Naguib Mechawar</name><affiliation wicri:level="1"><nlm:aff id="I1">Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3</wicri:regionArea><wicri:noRegion>QC H4H 1R3</wicri:noRegion></affiliation></author><author><name sortKey="Rosa Neto, Pedro" sort="Rosa Neto, Pedro" uniqKey="Rosa Neto P" first="Pedro" last="Rosa-Neto">Pedro Rosa-Neto</name><affiliation wicri:level="1"><nlm:aff id="I1">Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3</wicri:regionArea><wicri:noRegion>QC H4H 1R3</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4</wicri:regionArea><wicri:noRegion>QC H3A 2B4</wicri:noRegion></affiliation></author><author><name sortKey="Bedard, Marc Andre" sort="Bedard, Marc Andre" uniqKey="Bedard M" first="Marc-Andre" last="Bedard">Marc-Andre Bedard</name><affiliation wicri:level="4"><nlm:aff id="I2">Université du Québec à Montreal (UQAM), Montreal, QC H3C 3P8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université du Québec à Montreal (UQAM), Montreal, QC H3C 3P8</wicri:regionArea><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute (MNI), Montreal, QC H3A 2B4</wicri:regionArea><wicri:noRegion>QC H3A 2B4</wicri:noRegion></affiliation></author></analytic><series><title level="j">EJNMMI Research</title><idno type="eISSN">2191-219X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Fluorine-18 fluoroethoxybenzovesamicol ([<sup>18</sup>F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified <italic>in vivo</italic> with [<sup>18</sup>F]FEOBV PET, yielding analogous results to postmortem histological techniques.</p></sec><sec><title>Methods</title><p>Fifteen male rats (3 months old) underwent a cerebral infusion of 192 IgG-saporin at the level of the nucleus basalis magnocellularis. They were scanned using [<sup>18</sup>F]FEOBV PET, then sacrificed, and their brain tissues collected for immunostaining and quantification of cholinergic denervation using optical density (OD).</p></sec><sec><title>Results</title><p>For both PET binding and postmortem OD, the highest losses were found in the cortical areas, with the highest reductions in the orbitofrontal, sensorimotor, and cingulate cortices. In addition, OD quantification in the affected areas accurately predicts [<sup>18</sup>F]FEOBV uptake in the same regions when regressed linearly.</p></sec><sec><title>Conclusions</title><p>These findings support [<sup>18</sup>F]FEOBV as a reliable imaging agent for eventual use in human neurodegenerative conditions in which cholinergic losses are an important aspect.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mesulam, Mm" uniqKey="Mesulam M">MM Mesulam</name></author><author><name sortKey="Geula, C" uniqKey="Geula C">C Geula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Everitt, Bj" uniqKey="Everitt B">BJ Everitt</name></author><author><name sortKey="Robbins, Tw" uniqKey="Robbins T">TW Robbins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitehouse, Pj" uniqKey="Whitehouse P">PJ Whitehouse</name></author><author><name sortKey="Price, Dl" 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uniqKey="Counts S">SE Counts</name></author><author><name sortKey="Perez, Se" uniqKey="Perez S">SE Perez</name></author><author><name sortKey="Ginsberg, Sd" uniqKey="Ginsberg S">SD Ginsberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Efange, Sm" uniqKey="Efange S">SM Efange</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Efange, Sm" uniqKey="Efange S">SM Efange</name></author><author><name sortKey="Garland, Em" uniqKey="Garland E">EM Garland</name></author><author><name sortKey="Staley, Jk" uniqKey="Staley J">JK Staley</name></author><author><name sortKey="Khare, Ab" uniqKey="Khare A">AB Khare</name></author><author><name sortKey="Mash, Dc" uniqKey="Mash D">DC Mash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichikawa, T" uniqKey="Ichikawa T">T Ichikawa</name></author><author><name sortKey="Ajiki, K" uniqKey="Ajiki K">K Ajiki</name></author><author><name sortKey="Matsuura, J" uniqKey="Matsuura J">J Matsuura</name></author><author><name sortKey="Misawa, H" uniqKey="Misawa H">H Misawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parent, M" uniqKey="Parent M">M Parent</name></author><author><name sortKey="Bedard, Ma" uniqKey="Bedard M">MA Bedard</name></author><author><name sortKey="Aliaga, A" uniqKey="Aliaga A">A Aliaga</name></author><author><name sortKey="Mechawar, N" uniqKey="Mechawar N">N Mechawar</name></author><author><name sortKey="Soucy, Jp" uniqKey="Soucy J">JP Soucy</name></author><author><name sortKey="Rosa Neto, P" uniqKey="Rosa Neto P">P Rosa Neto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitehouse, Pj" uniqKey="Whitehouse P">PJ Whitehouse</name></author><author><name sortKey="Hedreen, Jc" uniqKey="Hedreen J">JC Hedreen</name></author><author><name sortKey="White, Cl" uniqKey="White C">CL White</name></author><author><name sortKey="Price, Dl" uniqKey="Price D">DL Price</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tagliavini, F" uniqKey="Tagliavini F">F Tagliavini</name></author><author><name sortKey="Pilleri, G" uniqKey="Pilleri G">G Pilleri</name></author><author><name sortKey="Gemignani, F" uniqKey="Gemignani F">F Gemignani</name></author><author><name sortKey="Lechi, A" uniqKey="Lechi A">A Lechi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benarroch, Ee" uniqKey="Benarroch E">EE Benarroch</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Parent, Maxime J" sort="Parent, Maxime J" uniqKey="Parent M" first="Maxime J" last="Parent">Maxime J. Parent</name></noRegion><name sortKey="Aliaga, Antonio" sort="Aliaga, Antonio" uniqKey="Aliaga A" first="Antonio" last="Aliaga">Antonio Aliaga</name><name sortKey="Bedard, Marc Andre" sort="Bedard, Marc Andre" uniqKey="Bedard M" first="Marc-Andre" last="Bedard">Marc-Andre Bedard</name><name sortKey="Bedard, Marc Andre" sort="Bedard, Marc Andre" uniqKey="Bedard M" first="Marc-Andre" last="Bedard">Marc-Andre Bedard</name><name sortKey="Cyr, Marilyn" sort="Cyr, Marilyn" uniqKey="Cyr M" first="Marilyn" last="Cyr">Marilyn Cyr</name><name sortKey="Cyr, Marilyn" sort="Cyr, Marilyn" uniqKey="Cyr M" first="Marilyn" last="Cyr">Marilyn Cyr</name><name sortKey="Kostikov, Alexey" sort="Kostikov, Alexey" uniqKey="Kostikov A" first="Alexey" last="Kostikov">Alexey Kostikov</name><name sortKey="Mechawar, Naguib" sort="Mechawar, Naguib" uniqKey="Mechawar N" first="Naguib" last="Mechawar">Naguib Mechawar</name><name sortKey="Parent, Maxime J" sort="Parent, Maxime J" uniqKey="Parent M" first="Maxime J" last="Parent">Maxime J. Parent</name><name sortKey="Rosa Neto, Pedro" sort="Rosa Neto, Pedro" uniqKey="Rosa Neto P" first="Pedro" last="Rosa-Neto">Pedro Rosa-Neto</name><name sortKey="Rosa Neto, Pedro" sort="Rosa Neto, Pedro" uniqKey="Rosa Neto P" first="Pedro" last="Rosa-Neto">Pedro Rosa-Neto</name><name sortKey="Schirrmacher, Esther" sort="Schirrmacher, Esther" uniqKey="Schirrmacher E" first="Esther" last="Schirrmacher">Esther Schirrmacher</name><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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